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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
drug:
Phenmetrazine
Research Papers that Mention the Interaction
“ Phenmetrazine also produced a downward shift in the cocaine self-administration dose effect curve, virtually eliminating responding maintained by a 30-fold range of cocaine doses (0.0032–0.1 mg/kg/injection) while having only small and transient effects on food-maintained responding.”
Selective Suppression of Cocaine- versus Food-Maintained Responding by Monoamine Releasers in Rhesus Monkeys: Benzylpiperazine, (+)Phenmetrazine, and 4-Benzylpiperidine“… cocaine produced tolerance to the … stimulus properties of methylphenidate, phenmetrazine , and phentermine, such that doses approximately two-fold higher than those used acutely were necessary to reproduce the original effect; … the cocaine stimulus was decreased greater than four-fold; and fenfluramine still failed to substitute for the cocaine stimulus.”
“Pretreatment with morphine and pentobarbital produced no change in this behavior until dosages (2.0 mg/kg and 15.… administered which grossly depressed grooming, exploratory, and locomotor activity behaviors, d-amphetamine (0.5–4.0 mg/kg) and phenmetrazine (2.0–12.0 mg/… dose-related decrease in cocaine ….”
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