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Last Updated: 3 months ago

Possible Interaction: Cocaine and Phendimetrazine

supplement:

Cocaine

Research Papers that Mention the Interaction

Phendimetrazine attenuated ratings on a select set of subjective outcomes (e.g., ratings of talkative/friendly), but failed to reduce the reinforcing effects of cocaine or a majority of positive subjective cocaine effects.
Phendimetrazine , a prodrug of the monoamine-releaser phenmetrazine, attenuates the reinforcing effects of cocaine in preclinical models, has minimal abuse potential, and is safe when combined with cocaine.
We hypothesized that phendimetrazine would attenuate the reinforcing effects of cocaine.
Psychopharmacology  •  2019  |  View Paper
Daily PDM treatment decreased cocaine self-administration by 30-90% across monkeys for at least 4 weeks.
Neuroscience  •  2016  |  View Paper
Continuous 21-day treatment with ramping PDM doses (days 1–7: 0.32 mg/kg/h; days 8–21: 1.0 mg/kg/h) reduced cocaine choices, increased food choices, and nearly eliminated extended-access cocaine self-administration without affecting body weight.
Neuropsychopharmacology  •  2013  |  View Paper
RESULTS Both isomers of phenmetrazine, and the racemate and both isomers of phendimetrazine , produced dose- and time-dependent substitution for the discriminative stimulus effects of cocaine , with greater potency residing in the (+) isomers.
Drug and alcohol dependence  •  2013  |  View Paper