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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
drug:
Phendimetrazine
Research Papers that Mention the Interaction
“ Phendimetrazine attenuated ratings on a select set of subjective outcomes (e.g., ratings of talkative/friendly), but failed to reduce the reinforcing effects of cocaine or a majority of positive subjective cocaine effects.”
“ Phendimetrazine , a prodrug of the monoamine-releaser phenmetrazine, attenuates the reinforcing effects of cocaine in preclinical models, has minimal abuse potential, and is safe when combined with cocaine.”
“We hypothesized that phendimetrazine would attenuate the reinforcing effects of cocaine.”
Influence of phendimetrazine maintenance on the reinforcing, subjective, performance, and physiological effects of intranasal cocaine“ Phendimetrazine enhanced peak heart rate following placebo and low cocaine doses , but these effects were also not clinically significant.”
“Daily PDM treatment decreased cocaine self-administration by 30-90% across monkeys for at least 4 weeks.”
Attenuation of cocaine self-administration by chronic oral phendimetrazine in rhesus monkeys
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