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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Cocaine
drug:
Parthenolide
Research Papers that Mention the Interaction
“We recently reported that the natural cyclic lactone, parthenolide , and related analogs prevent the expression of behavioral effects induced by cocaine in planarians and that parthenolide's γ-lactone ring is required for this effect.”
Minimal structural requirements of alkyl γ-lactones capable of antagonizing the cocaine-induced motility decrease in planarians“ Parthenolide , a compound isolated from the feverfew plant (Tanacetum parthenium), has been shown to substantially inhibit cocaine ’s locomotion effects in a planarian animal model (Pagán et al., 2008).”
“Results showed that parthenolide at 0.125 mg/kg and 0.250mg/kg significantly blocked cocaine ’s inhibitory effect on DA neuronal firing rate and bursting activity (p< 0.05, two way ANOVA).”
“We propose that parthenolide might inhibit cocaine ’s effects on VTA DA neurons via its interaction with a common binding site at monoamine transporters.”
Parthenolide Blocks Cocaine’s Effect on Spontaneous Firing Activity of Dopaminergic Neurons in the Ventral Tegmental Area
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