Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago

Possible Interaction: Cocaine and Pargyline

supplement:

Cocaine

Research Papers that Mention the Interaction

The inhibition of both MAO-A and MAO-B by clorgyline and pargyline , respectively, enhanced the effects of cocaine on DARPP-32 phosphorylation.
Neuroscience Letters  •  2013  |  View Paper
Pargyline (5 × 10-4 M) augmented the facilitatory effect of reboxetine (3 × 10-9-10-6 M) and cocaine (10-7-3 × 10-5 M).
Journal of Pharmacology and Experimental Therapeutics  •  2003  |  View Paper
2 In vivo cocaine administration resulted in decreased turnover of 5‐HT, as indicated by the decreased accumulation of 5‐HT after pargyline administration and the decreased accumulation of 5‐hydroxyindoleacetic acid (5‐HIAA) following probenecid injection.
British journal of pharmacology  •  1975  |  View Paper
Pargyline pre-treatment significantly antagonized the hypothermic action of cocaine.
West African journal of pharmacology and drug research  •  1975  |  View Paper
3 After pre‐treatment with nialamide (100 mg/kg) or pargyline (25 mg/kg) cocaine evoked high rates of turning towards the lesioned side.
British journal of pharmacology  •  1973  |  View Paper
The norepinephrine-releasing effect of cocaine is increased by pretreatment with the monoamine oxidase inhibitor, pargyline , and decreased at lower temperatures.
The Journal of pharmacology and experimental therapeutics  •  1968  |  View Paper