Possible Interaction: Cocaine and Oxytocin

“Behavioral sensitization to cocaine , on the other hand, was facilitated by OXT.”

“Following chronic cocaine treatment, the behavioral tolerance to the sniffing-inducing effect of cocaine was markedly inhibited by OXT.”

“Behavioral tolerance to cocaine was also attenuated by OXT.”

“In light of this information, it appears that OXT inhibits the development of opiate tolerance, dependence, and self-administration as well as the acute behavioral actions of and chronic tolerance to cocaine.”

“On the contrary, OXT stimulated the development of behavioral sensitization to cocaine.”

“The maximal response to oxytocin , but not the sensitivity, was increased by cocaine by an effect that could not be blocked by prazosin.”

“The preclinical research corroborates the clinical findings that systemic administration of oxytocin decreases relapse to cocaine , methamphetamine, heroin, and alcohol seeking (reviewed in [2]).”

“Administration of OXT before each social defeat blocked the social defeat‐induced increment in the conditioned rewarding effects of cocaine in the CPP, favored the extinction of cocaine‐associated memories in both the CPP and SA, and decreased reinstatement of cocaine‐seeking behavior in the SA.”

“Moreover, OXT prevents RSD‐induced increases in the motivational effects of cocaine.”

“In females, systemic oxytocin (0.3, 1.0, 3.0 mg/kg) attenuated lever pressing for cocaine during self-administration and oxytocin (1.0 mg/kg) attenuated cue-induced cocaine seeking following extinction.”

“Results: Systemic oxytocin dose-dependently reduced cocaine self-administration during various schedules of reinforcement, including fixed ratio 1, fixed ratio 5, and progressive ratio.”

“Intergenerational effects of cocaine were apparent with respect to aggression and oxytocin system changes.”

“ Cocaine may alter both oxytocin and maternal aggression either directly or indirectly through changes in monoamine levels in relevant brain regions.”

“A growing body of evidence suggests that cocaine may alter oxytocin levels leading to impairments in maternal behavior and aggression.”

“On PPD 1, 30 mg/kg cocaine reduced OT levels by approximately 26.9% (picograms/milligram) in the MPOA (t (18) = 3.44, P<.01) compared to saline.”

“On PPD 6, 30 mg/kg cocaine significantly increased OT levels by approximately 20.9% (picograms/brain area) in the AMY (F (2,25) = 3.44, P=.05) relative to saline.”