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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
drug:
Ondansetron
Research Papers that Mention the Interaction
“After abstinence 7 d, the drugs reduced locomotor activity in the OF, in the EMP propranolol and ondansetron reversed the anxiogenic effect induced by cocaine.”
Reversal of cocaine withdrawal-induced anxiety by ondansetron, buspirone and propranolol“We have recently shown that ondansetron (a 5-HT3 receptor antagonist) given 3.5 h after each daily cocaine injection reverses previously established behavioral sensitization.”
“Pretreatment with ondansetron or MDL 72222 reduced the increase in striatal DA release induced by 10 mg/kg morphine but not by 1 mg/kg morphine, haloperidol, amphetamine or cocaine.”
“ Ondansetron inhibited cocaine self-administration on each of the following days.”
“Abstract The present experiment evaluated the ability of the 5-HT3 antagonist, ondansetron , administered during withdrawal from chronic cocaine administration, to block the expression of sensitization and tolerance induced by the intermittent or continuous administration of cocaine , respectively.”
“Abstract The present experiment evaluated the ability of the 5-HT3 antagonist, ondansetron , administered during chronic cocaine administration, to block the development of sensitization and tolerance induced by the intermittent or continuous administration of cocaine , respectively.”
“In contrast, daily injections of ondansetron with cocaine significantly blocked the development of sensitization with an inverted U-shape dose-response curve.”
“Prazosin and both doses of ondansetron antagonized the behavioral effects of cocaine at doses that ranged from 1.0-3.0 mg/kg.”
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