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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
Research Papers that Mention the Interaction
“The in vitro vasoconstriction induced by cocaine was blocked by pretreatment with L-NMMA , whereas L-NMMA did not block the norepinephrine-induced vasoconstriction in vitro.”
“When rats were pretreated with NG-monomethyl-L-arginine (L-NMMA, a blocker of nitric oxide) and challenged with cocaine , the increase in blood pressure was blocked by 80%, whereas pretreatment with L-NMMA did not block norepinephrine-induced vasoconstriction.”
Role of nitric oxide in cocaine-induced acute hypertension.“The increase in … induced by cocaine (160 μg, i.e.) was attenuated dose‐dependently by prior cavemosal administration of the NO synthase …, Nω‐nitro‐L‐arginine methyl ester (1‐NAME, 0.5, 1 or 5 pmol) or NG‐monomethyl‐L‐arginine (L‐NMMA, 2.5, 5 or 10 pmol).”
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