Possible Interaction: Cocaine and Olanzapine

“In fact, olanzapine may worsen cocaine treatment outcome.”

“Medications such as olanzapine , which block dopamine D2 receptors, as well as serotonin receptors 5HT2A and 5HT2C may be able to reduce cocaine use in cocaine dependent patients by reducing the euphoric effects of cocaine and attenuating cocaine craving.”

“Srivilasa et al. described a case of compartment syndrome of the leg resulting from multi-drug overdose olanzapine and cocaine).”

“These scheduled doses of olanzapine improved his psychoses and decreased anxiety and frequency of “using” dreams and persistent thoughts of using cocaine.”

“We report a 48 years old male drinker and addicted to cocaine , that after two months of Olanzapine use , developed a severe diabetes mellitus with fasting blood glucose values reaching 514 mg/dl.”

“In this model of acute cocaine toxicity, olanzapine pretreatment attenuated acute cocaine toxicity.”

“ Olanzapine also appeared to alter the characteristics of seizures due to cocaine.”

“ Olanzapine caused dose-related decreases in cocaine self-administration at pretreatment doses that had no overt behavioral effects indicative of sedation.”

“The dose of olanzapine that markedly suppressed cocaine self-administration behavior increased dopamine to approximately 190% of control values.”

“The results indicate that olanzapine can effectively suppress cocaine self-administration behavior in nonhuman primates at doses that enhance dopamine release but do not maintain drug self-administration.”

“drug self-administration paradigm in nonhuman primates to obtain definitive evidence regarding the effectiveness of olanzapine to modulate the reinforcing effects of cocaine.”

“Near basal levels of defense were observed for animals treated with either amperozide, clozapine (3.0 and 10.0 mg/kg but not 30.0 mg/kg) or olanzapine followed by cocaine.”

“Similar decreases in cocaine self-administration rates were obtained with the dopamine receptor antagonists olanzapine , clozapine, risperidone, fluphenazine and haloperidol.”

“Pre-treatment with olanzapine (3.0, 4.5 mg/kg, but not 1.5 mg/kg) significantly attenuated conditioned place preference produced by cocaine (10 mg/kg).”

“These results suggest that pre-treatment with olanzapine is capable of blocking the reinforcing effects of cocaine and illustrates the value of using multiple tests of reinforcement when evaluating the pharmacological effects of newer psychotherapeutic agents.”