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Last Updated: 3 months ago

Possible Interaction: Cocaine and Nomifensine

supplement:

Cocaine

Research Papers that Mention the Interaction

These findings, along with the marked pharmacological similarities between nomifensine and such drugs as cocaine and methylphenidate, indicate a potential for nomifensine abuse by humans.
Science  •  1981  |  View Paper
Furthermore, although the inhibition of DA reuptake by cocaine and nomifensine caused a short-term prolongation of DA responses, the combined inhibition of MAO A and B enzymes caused a long-term prolongation of DA effects.
The Journal of Neuroscience  •  1997  |  View Paper
Cocaine and nomifensine were found to competitively inhibit dopamine uptake in both regions.
The Journal of pharmacology and experimental therapeutics  •  1995  |  View Paper
In contrast, mazindol and nomifensine were found to bind to separate interactive sites when individually paired with cocaine.
Journal of neurochemistry  •  1994  |  View Paper
Specific binding was prevented by various dopamine uptake blockers, pyrovalerone, GBR 13069, GBR 12783, N-[1-2-benzo(b)thiophenyl)cyclohexyl] piperidine, cocaine , methylphenidate and was inhibited in a stereoselective manner by the enantiomers of nomifensine.
European journal of pharmacology  •  1992  |  View Paper
The fixed-ratio rates maintained by this dose of nomifensine were slightly lower than those maintained by cocaine.
Drug and alcohol dependence  •  1985  |  View Paper
Combination of nomifensine and sulpiride or cocaine and sulpiride increased total overflow of endogenous compounds by 217 and 120%, respectively, as compared to the neuronal uptake inhibitors alone.
The Journal of pharmacology and experimental therapeutics  •  1985  |  View Paper