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Possible Interaction: Cocaine and Nomifensine

supplement:

Cocaine

Research Papers that Mention the Interaction

These findings, along with the marked pharmacological similarities between nomifensine and such drugs as cocaine and methylphenidate, indicate a potential for nomifensine abuse by humans.
Science  •  1981  |  View Paper
We demonstrated that, similar to cocaine, the DAT blockers nomifensine and bupropion were less effective at inhibiting dopamine uptake following cocaine SA.
Neuropsychopharmacology  •  2012  |  View Paper
Furthermore, although the inhibition of DA reuptake by cocaine and nomifensine caused a short-term prolongation of DA responses, the combined inhibition of MAO A and B enzymes caused a long-term prolongation of DA effects.
The Journal of Neuroscience  •  1997  |  View Paper
Cocaine and nomifensine were found to competitively inhibit dopamine uptake in both regions.
The Journal of pharmacology and experimental therapeutics  •  1995  |  View Paper
The specific binding of [3H]cocaine was inhibited monophasically by GBR 12783, mazindol, nomifensine and substrates of the transporter; in saturation experiments, GBR 12783 competitively blocked the [3H]cocaine specific binding and vice versa.
European journal of pharmacology  •  1994  |  View Paper
In contrast, mazindol and nomifensine were found to bind to separate interactive sites when individually paired with cocaine.
Journal of neurochemistry  •  1994  |  View Paper
In the …, cocaine dose-dependently inhibited ACh release, with an IC50 of 2.9 microM. At 10 microM cocaine, D2 receptor blockade … sulpiride resulted in only about a 45% reversal of the inhibition of ACh release, whereas inhibition due to either nomifensine or quinpirole was reversed by about 80%.
The Journal of pharmacology and experimental therapeutics  •  1992  |  View Paper
Specific binding was prevented by various dopamine uptake blockers, pyrovalerone, GBR 13069, GBR 12783, N-[1-2-benzo(b)thiophenyl)cyclohexyl] piperidine, cocaine , methylphenidate and was inhibited in a stereoselective manner by the enantiomers of nomifensine.
European journal of pharmacology  •  1992  |  View Paper
In the presence of 10 microM cocaine and 10 microM nomifensine , the cellular responses to L-DOPA application were augmented and prolonged.
Neuroscience Letters  •  1991  |  View Paper
On the other hand, cocaine and the selective DA uptake inhibitor, nomifensine completely antagonized the effect of 5 muM 5-HT on spontaneous tritium efflux with IC50 values of 0.2 and 0.09 muM, respectively.
European journal of pharmacology  •  1991  |  View Paper
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