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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
drug:
Nitroarginine
Research Papers that Mention the Interaction
“Intraperitoneal administration of N omega-nitro-L-arginine (L-NNA, 7.5 and … nitric oxide synthase inhibitor, inhibited the cocaine-induced ambulation-accelerating activity and the L-NNA administered before and … injection of cocaine in mice blocked the development of reverse tolerance …-accelerating effect of cocaine (15 mg/kg).”
Nitric oxide mediation of cocaine-induced dopaminergic behaviors: ambulation-accelerating activity, reverse tolerance and conditioned place preference in mice.“Pretreatment with NG-nitro-L-arginine methyl ester (L-NAME; 100 mg/kg/day; intraperitoneally) or NG-nitro-L-arginine (NO-Arg; 25 mg/kg/day; intraperitoneally) completely abolished the sensitization to the convulsive and lethal responses to cocaine.”
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