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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Cocaine
drug:
Nitric Oxide
Research Papers that Mention the Interaction
“Blockade of uptake 1 by cocaine is also partly dependent on NO.”
In-vivo evidence of a role for nitric oxide in regulating the activity of the norepinephrine transporter.“Cumulatively, these results suggest that nitroxides such as Tempol can attenuate oxidative damage and cell death induced by cocaine and that PC12 cells can be used as an in vitro model to further investigate the precise molecular mechanism of these compounds.”
“ResultsRepeated exposure to cocaine (20 mg/kg), once a day for seven consecutive days, increased NO levels.”
“Acute systemic administration of cocaine significantly increased NO efflux in the mPFC in a time‐dependent manner.”
“At 48-h treatment, cocaine (3–30 μM) produced a concentration-dependent decrease in nitric oxide release in BCAECs.”
“Collectively, the results suggest that cocaine inhibits nitric oxide release in BCAECs by decreasing intracellular calcium mobilization, increasing the inactive state of eNOS, and decreasing eNOS protein levels.”
“In accordance with its inhibition of nitric oxide release, cocaine decreased endothelial nitric-oxide synthase (eNOS) protein levels in BCAECs in a concentration-dependent manner.”
“In the absence of cocaine, basal nitric oxide release from BCAECs continued to accumulate in the medium over the period from 6 to 72 h. Cocaine significantly decreased nitric oxide release at each time point of the study.”
“These data suggest that cocaine may impact resistance to gram-negative infections and severity of these infections via modulation of nitric oxide parameters.”
“It has been suggested that cocaine causes endothelial dysfunction and vasoconstriction by inhibiting local production of nitric oxide and that endothelial dysfunction may be involved in the cardiovascular events associated with cocaine use.”
“These findings indicate that cocaine reduces nitric oxide release from vascular endothelium apparently through the inhibiting action of Ca2+-ATPase pump.”
“In accordance, cocaine decreased nitric oxide production in BCAECs at each time point of the study.”
“Whether nitric oxide NO ) inhibition may potentiate the effects of cocaine on coronary circulation and ventricular function is still unknown.”
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