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Last Updated: 2 months ago

Possible Interaction: Cocaine and Nitric Oxide

supplement:

Cocaine

Research Papers that Mention the Interaction

Blockade of uptake 1 by cocaine is also partly dependent on NO.
European journal of pharmacology  •  2011  |  View Paper
Cumulatively, these results suggest that nitroxides such as Tempol can attenuate oxidative damage and cell death induced by cocaine and that PC12 cells can be used as an in vitro model to further investigate the precise molecular mechanism of these compounds.
European journal of pharmacology  •  2011  |  View Paper
ResultsRepeated exposure to cocaine (20 mg/kg), once a day for seven consecutive days, increased NO levels.
Psychopharmacology  •  2009  |  View Paper
Acute systemic administration of cocaine significantly increased NO efflux in the mPFC in a time‐dependent manner.
Synapse  •  2008  |  View Paper
At 48-h treatment, cocaine (3–30 μM) produced a concentration-dependent decrease in nitric oxide release in BCAECs.
Collectively, the results suggest that cocaine inhibits nitric oxide release in BCAECs by decreasing intracellular calcium mobilization, increasing the inactive state of eNOS, and decreasing eNOS protein levels.
In accordance with its inhibition of nitric oxide release, cocaine decreased endothelial nitric-oxide synthase (eNOS) protein levels in BCAECs in a concentration-dependent manner.
In the absence of cocaine, basal nitric oxide release from BCAECs continued to accumulate in the medium over the period from 6 to 72 h. Cocaine significantly decreased nitric oxide release at each time point of the study.
Journal of Pharmacology and Experimental Therapeutics  •  2005  |  View Paper
These data suggest that cocaine may impact resistance to gram-negative infections and severity of these infections via modulation of nitric oxide parameters.
International immunopharmacology  •  2003  |  View Paper
It has been suggested that cocaine causes endothelial dysfunction and vasoconstriction by inhibiting local production of nitric oxide and that endothelial dysfunction may be involved in the cardiovascular events associated with cocaine use.
Journal of cardiovascular pharmacology and therapeutics  •  2003  |  View Paper
These findings indicate that cocaine reduces nitric oxide release from vascular endothelium apparently through the inhibiting action of Ca2+-ATPase pump.
Toxicology letters  •  2001  |  View Paper
In accordance, cocaine decreased nitric oxide production in BCAECs at each time point of the study.
The Journal of pharmacology and experimental therapeutics  •  2001  |  View Paper
Whether nitric oxide NO ) inhibition may potentiate the effects of cocaine on coronary circulation and ventricular function is still unknown.
European journal of clinical investigation  •  2000  |  View Paper
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