Possible Interaction: Cocaine and Nitrendipine

“… nitrendipine (… cocaine to the whole animal (1.46 x 10(-3) mg/kg/min of NIT; 2 mg/kg/min of cocaine) and isolated retrograde perfused …) to 1 x 10(-4) M cocaine) normalized cocaine-induced abnormalities in heart rhythm and provided protection from acute cocaine-induced morphological lesions.”

“We found that intra-arterial administration of the calcium antagonist Nitrendipine greatly inhibited the vasoconstriction induced by cocaine in all three arteriole orders.”

“In the latter, the cardiovascular anomalies and cardiac lesions caused by cocaine are prevented by selected calcium channel antagonists such as nitrendipine (10, 11).”

“Spasm induced by cocaine was prevented by the calcium entry blocker nitrendipine , but not by phentolamine, an alpha-adrenergic antagonist.”

“ Abstract Nitrendipine , a ca2+ modulator was tested in the rat as an antagonist to the cardiac toxicity of cocaine and as an antidote to the acute lethal effects of this drug.”

“In …, nitrendipine (1.46 x 10-3 … simultaneously administered intraarterially with cocaine (2 mg/kg/min) suppresses the arrhythmias induced by cocaine and increases survival time from 73 ± 33 min to … the lethal dose of cocaine from 146 ± 66 mg/kg to 618 ± 236 mg/kg (p < 0.003).”

“ Nitrendipine also protects the heart from the acute morphological lesions induced by cocaine administration and antagonizes some of the central effects of cocaine.”