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Last Updated: 2 years ago

Possible Interaction: Cocaine and Nimodipine

supplement:

Cocaine

Research Papers that Mention the Interaction

This double blind, placebo controlled study of acute calcium channel antagonist use during cocaine administration in five patients found that 60 mg of nimodipine treatment attenuated the systolic, but not diastolic, blood pressure effects of cocaine.
The American journal on addictions  •  1999  |  View Paper
Behavioral sensitization to cocaine was blocked by coadministration of nimodipine , anL-type calcium channel blocker.
Molecular Neurobiology  •  2007  |  View Paper
Nimodipine , but not haloperidol, blocked the expression of behavioural sensitization to cocaine after a cocaine challenge.
Psychopharmacology  •  2005  |  View Paper
Nifedipine and nimodipine dose-dependently increased the lethalities produced by 80 mg/kg cocaine.
Progress in Neuro-Psychopharmacology and Biological Psychiatry  •  2002  |  View Paper
Thus, the Ca2+ channel blocker nimodipine decreases the sensitivity of mice and rats to the reinforcing effects of cocaine while the Ca2+ channel activator BayK 8644 makes the animals more sensitive to cocaine reward.
European journal of pharmacology  •  1996  |  View Paper
Nimodipine was the most potent agent in antagonizing the pressor effect of cocaine.
The Journal of pharmacology and experimental therapeutics  •  1995  |  View Paper
Co-administration with nimodipine , an agent that blocks the impulse-dependent increase in synaptic concentrations of dopamine caused by cocaine , not only blocked sensitization but also blocked the increase in occupation of receptors.
Brain Research  •  1994  |  View Paper
The 1,4-dihydropyridine nimodipine and the benzothiazepine diltiazem were more effective in inhibiting cocaine (20 mg/kg)-induced responses than amphetamine (0.6 mg/kg)-induced responses.
Life sciences  •  1993  |  View Paper
Pretreatment of mice with isradipine (1.0-3.0 mg/kg, SC) or nimodipine (5-20 mg/kg, SC) inhibited in a dose-related manner self-administration both of cocaine and morphine contingent upon a nose-poke response.
These data suggest that nimodipine and, especially, isradipine suppress the reinforcing properties of morphine and cocaine and may be an effective pharmacotherapy for treatment of cocaine and heroin abuse.
Pharmacology Biochemistry and Behavior  •  1992  |  View Paper
Thus, cocaine toxicity was partially reversed by nimodipine.
The American journal of the medical sciences  •  1992  |  View Paper
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