Possible Interaction: Cocaine and Nifedipine

“ Nifedipine pretreatment attenuated some subjective effects of cocaine.”

“Intracerebroventricular administration of nifedipine (3, 10, and 30 nmol/mouse) dose‐dependently reduced the development of methamphetamine‐, cocaine‐ , and morphine‐induced rewarding effect.”

“In animals treated with nifedipine and cocaine , cytochrome P450 increased 11 % (p<0.01) vs. control, decreased 12.5 % (p<0.001) vs. nifedipine group and increased 34 % (p<0.0001) vs. cocaine group.”

“These results suggest that the cocaine and nifedipine interact at the metabolic level.”

“Repetition of the experiment in the presence of cocaine (10(-5) M) revealed the inhibitory effect of nifedipine on noradrenaline-induced contraction, the maximum contraction in the presence of nifedipine falling significantly (P<0.005) to 67+/-6% of the pre-nifedipine response.”

“Furthermore, calcium blocker, nifedipine , blocks the effect of cocaine , suggesting that extracellular calcium enters the cytosol through the L-channel.”

“In the presence of 40 mg/kg nifedipine , the LD50 of cocaine was decreased from 80.7 to 66.3 mg/kg.”

“ Nifedipine and nimodipine dose-dependently increased the lethalities produced by 80 mg/kg cocaine.”

“ Nifedipine prevented the ability of morphine and cocaine , but not of ethanol, to produce a place preference.”

“For all practical purposes, nifedipine completely abolished the increase in peak tension developed induced by cocaine.”

“administered 5 h earlier] also reduced the myocardial depressant effect of cocaine at 2 min [regional EF decreased from 50 +/- 2% at baseline to 38 +/- 4% (cocaine alone), 56 +/- 3 to 49 +/- 4% ( nifedipine and cocaine), p < 0.05].(ABSTRACT TRUNCATED AT 250 WORDS)”

“Subthreshold concentrations of the calcium channel opener, Bay K 8644, also were increased greatly by cocaine , and this magnification was antagonized by nifedipine.”