Possible Interaction: Cocaine and Ng-Nitroarginine Methyl Ester

“ L-NAME treated animals continuously infused with cocaine showed higher BSR thresholds to a challenge 3 days following pump removal.”

“ L-NAME appeared to prolong the rewarding effect of cocaine possibly through a pharmacokinetic action.”

“Conclusions: These findings suggest that L-NAME and 7-NI may increase the potency of cocaine and other indirect DA agonists through a central mechanism whereby DA neurotransmission is directly enhanced by NOS inhibition.”

“Results: The results demonstrated that neither NOS inhibitor alone substituted for the 10 mg/kg cocaine training dose, but when given as a pretreatment, 100 mg/kg L-NAME as well as 10 mg/kg 7-NI enhanced the discriminative stimulus and rate-decreasing effects of cocaine.”

“Pretreatment of mice with L-NAME enhanced the stimulatory effects of both acute and repeated cocaine on corticosterone level.”

“Pretreatment injections of L-NAME (100 mg/kg) or 7-NI (30 mg/kg), administered 30 min before each cocaine pre-exposure injection, acutely inhibited cocaine-induced behavioral activation.”

“Pretreatment with Ng-nitro-1-arginine methyl ester (l-NAME; 10-50 mg/kg, intraperitoneally, twice daily for 4 days), significantly and dose-dependently suppressed the maintenance of intravenous cocaine self-administration and the absolute reward magnitude of cocaine.”

“The increase in … induced by cocaine (160 μg, i.e.) was attenuated dose‐dependently … prior cavemosal administration of the NO synthase inhibitor, Nω‐nitro‐L‐arginine methyl ester (1‐NAME, 0.5, 1 or 5 pmol) or NG‐monomethyl‐L‐arginine (L‐NMMA, 2.5, 5 or 10 pmol).”

“No inhalation (80 ppm) did not affect CNS and cardiovascular responses to cocaine in control animals but enhanced the effects of L-NAME on cocaine toxicity.”

“The results … pretreatment with L-NAME reduces the central … stimulatory effect of cocaine (reduced seizure incidence) and enhances its depressant effect on both the central nervous system (lower does for isoEEG) … cardiovascular system (lower dose for arrhythmias and asystole), but does not affect the cardiovascular stimulatory action of cocaine.”

“Pretreatment with NG-nitro-L-arginine methyl ester (L-NAME; 100 mg/kg/day; intraperitoneally) or NG-nitro-L-arginine (NO-Arg; 25 mg/kg/day; intraperitoneally) completely abolished the sensitization to the convulsive and lethal responses to cocaine.”