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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
drug:
Neuropeptide Y
Research Papers that Mention the Interaction
“Several lines of evidence suggest a possible involvement of the NPY system in the physiological effects of several classes of abused substances including alcohol, phencyclidine, cocaine , and marijuana and in endogenous psychosis.”
Association between neuropeptide Y gene and its receptor Y1 gene and methamphetamine dependence“Additional studies suggest that cocaine may affect NPY expression.”
“Results revealed that NPY injections augmented cocaine-induced hyperactivity and moderately increased cocaine self-administration.”
Neuropeptide Y augments cocaine self-administration and cocaine-induced hyperlocomotion in rats“At 15 days, the GnRH IPI was significantly decreased after incubation with cocaine and amphetamine‐regulated transcript (CART), α‐melanocyte‐stimulating hormone, corticotrophin‐releasing factor (CRF) and neuropeptide Y ( NPY).”
“However, cocaine produces long-lasting changes in NPY expression that are of unknown functional significance.”
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