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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
drug:
Naltrexone
Research Papers that Mention the Interaction
“These results suggest that isradipine alone or in combination with naltrexone attenuates some of the physiological effects of cocaine.”
Effects of naltrexone and isradipine, alone or in combination, on cocaine responses in humans“Recently, we reported that naltrexone at 150 mg/day significantly decreased cocaine and alcohol use for men but not women with co-occurring cocaine and alcohol dependence.”
“Thus, 150 mg/day naltrexone added to a psychosocial treatment resulted in reductions in cocaine and alcohol use and drug severity in men, compared to higher rates of cocaine and alcohol use and drug severity in women.”
“Conclusion: Both NTX and NMF block the place preference, but not locomotor activating, effects of cocaine.”
“Several preclinical and clinical studies have demonstrated that the mu opioid receptor (MOPr) antagonist/kappa opioid receptor (KOPr) partial agonist naltrexone (NTX) reduces the subjective effects and self‐administration of cocaine.”
Naltrexone and nalmefene attenuate cocaine place preference in male mice“RESULTS Na trexone de creased the essential value of coc aine in IC rats only.”
“This result suggests that cocaine may overcome naltrexone's effectiveness as a treatment for alcoholism.”
“However, pretreatment with GYKI 52466 or naltrexone at doses that suppressed conditioned activity in FR animals suppressed cross-sensitization to cocaine.”
“When administered alone, cocaine and amphetamine increased respiration and also increased the respiratory stimulant effects of naltrexone ; cocaine and amphetamine did not attenuate any measure of withdrawal.”
“Pretreatments with naltrexone (0.1–10 mg/kg, SC) 20 min prior to the start of self-administration sessions resulted in decreases in cocaine self-administration at doses of 0.1 and 0.3 mg/kg/infusion, but not at 1.0 mg/kg/infusion.”
“ Cocaine and amphetamine antagonized the discriminative stimulus effects of naltrexone , each shifting the naltrexone dose-effect curve significantly (e.g., 100-fold) rightward or downward.”
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