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Last Updated: 2 years ago

Possible Interaction: Cocaine and Naloxone

supplement:

Cocaine

Research Papers that Mention the Interaction

The arrhythmia is attributed to unopposed sympathomemetic effects of cocaine following administration of naloxone.
Journal of clinical forensic medicine  •  2005  |  View Paper
The highest dose of naloxone also blocked reacquisition of cocaine CPP, and did not produce a conditioned place aversion in heroin-naïve and heroin pre-treated animals.
Neurobiology of Learning and Memory  •  2010  |  View Paper
In contrast, the opioid antagonist naloxone , and to a lesser extent, the kappa opioid spiradoline attenuated the effects of cocaine at doses that did not alter locomotor activity when administered alone.
Psychopharmacology  •  2003  |  View Paper
Administration of the non-selective opioid receptor antagonists, naloxone and naltrexone, attenuate the rewarding effects of cocaine.
Neuroscience Letters  •  2002  |  View Paper
Surprisingly, when naloxone was administered prior to cocaine , an increase in cocaine-induced locomotor and stereotyped activity was observed, but only in OVX-EB rats.
Brain Research  •  2002  |  View Paper
The secondary, but not the initial, cocaine antinociception was blocked by naloxone (2 mg/kg, IP).
Pharmacology Biochemistry and Behavior  •  1993  |  View Paper
We attempted to reverse the behavioral and neuronal antinociceptive effects of cocaine with naloxone , an opioid antagonist.
European journal of pharmacology  •  1991  |  View Paper
The coronary dilation and constriction produced by 10 mg/kg of cocaine could be prevented by either preadministra tion or postadministration of naloxone , but this did not prevent subsequent death.
Angiology  •  1991  |  View Paper
Antagonism of the threshold lowering effect of cocaine for brain stimulation reward by naloxone was investigated.
Life sciences  •  1987  |  View Paper