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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
drug:
Nalbuphine
Research Papers that Mention the Interaction
“ Nalbuphine and other mu-kappa agonists decreased cocaine self-administration in preclinical models.”
Effects of nalbuphine on anterior pituitary and adrenal hormones and subjective responses in male cocaine abusers“Rats treated with cocaine exhibited a progressive increase in locomotor activity over the 10-day treatment period, and this effect was significantly reduced in rats treated with cocaine+nalbuphine.”
“The purpose of the present study was to evaluate the ability of the mixed mu/kappa agonist nalbuphine to modulate sensitization to the locomotor and positive reinforcing effects of cocaine.”
“These data suggest that nalbuphine attenuates the development of sensitization to the behavioral effects of cocaine.”
“This increase in responding at a threshold dose of cocaine was blocked completely in rats treated with cocaine+nalbuphine.”
The mu/kappa agonist nalbuphine attenuates sensitization to the behavioral effects of cocaine“Using the labor supply economic model, combinations of heroin, alfentanil, or nalbuphine with relatively low doses of cocaine were found to increase the number of injections per session (“income”) and total responses per session (“labor”).”
“ConclusionsThese data suggest that low-efficacy opioids possessing significant mu-agonist activity (e.g. buprenorphine, butorphanol, nalbuphine , (−)-pentazocine) may potentiate the effects of cocaine in a manner similar to that typically observed with high-efficacy mu opioids.”
“The high-efficacy mu opioid levorphanol, and the low-efficacy opioids buprenorphine, butorphanol, nalbuphine and (−)-pentazocine, dose-dependently enhanced the effects of cocaine at doses that did not alter locomotor activity when administered alone.”
“ Nalbuphine and butorphanol produced the greatest decreases in cocaine self-administration and the smallest effects on food-maintained responding.”
“Buprenorphine, butorphanol and nalbuphine tested against the optimal unit dose of cocaine (0.8 microg per infusion), inhibited initiation of cocaine self-administration in a dose-dependent manner.”
“and nalbuphine (2 mg/kg, s. c.) produced a shift of the optimal cocaine dose from 0.8 to 0.4 microg/inf, while butorphanol (1 mg/kg, s.c.)”
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