Possible Interaction: Cocaine and N-Methyl-3,4-Methylenedioxyamphetamine

“Considering that the increase in dopamine levels in striatum and mesolimbic dopaminergic structures is believed to be of central importance to the rewarding properties of MD A as well as of d-amphetamine and coc aine, o ther factors could account for the discrepancy.”

“Anxiety disorders were associated with medication and cannabis use, while high-risk behaviours predicted use of cocaine and ecstasy , or wide-ranging polysubstance use including ketamine and medications.”

“Support for needle and syringe exchange programs (OR 8.5) and a heroin prescription trial (OR 8.1); approval of the regular use by … of the personal use of amphetamines (OR 5.2); and histories of having used amphetamines (OR 7.2), cannabis (OR 6.1) and cocaine (… Ecstasy.”

“Individuals that are more likely to use cocaine are also more likely to use ecstasy.”

“Also, the mixture of MDMA with other designer drugs, ethanol and/or cocaine is shown to be more likely to produce toxic symptoms requiring clinical attendance in a hospital emergency room.”

“Amphetamines (eg, speed, ice, ecstasy ) have many of the cardiovascular toxicities seen with cocaine , including acute and chronic cardiovascular diseases.”

“Compounds potentially used with MDMA [fluoxetine, paroxetine, (-)-cocaine ] demonstrated significant inhibition of MDMA metabolism in both human liver and CYP2D6.1-expressing microsomes.”

“A case is presented of a young man aged 25 years who had an episode of jaundice and renal failure after using a small amount of ecstasy and cocaine.”

“ MDMA and methamphetamine inhibited binding of a cocaine analog to the dopamine transporter and released dopamine accumulated by cells expressing dopamine transporters, but similar concentrations of MMAI were inactive.”

“Latterly he had supplemented his intake of MDMA with occasional doses of cocaine.”