Possible Interaction: Cocaine and Morphine

“Interaction effects between cocaine and morphine were observed in terms of positive changes toward selected aspects of mood (e.g., cheerful, friendly) in postoperative patients but toward negative aspects of mood (e.g., sad, serious) in patients with chronic pain.”

“These results suggest that cocaine exposure of mice carrying the 118G allele leads to a heightened sensitivity of the reward system and a blunted modulation of Ca(2+) channels by morphine in sensory neurons.”

“The association of cocaine and other amphetamine-type stimulants with morphinics or cannabis is very dangerous.”

“In the case of combination of morphine and cocaine or caffeine, preference rates for these drugs increased like the case of morphine.”

“Spontaneous morphine intake ratio after 3 weeks administration of cocaine was 20% lower in total daily intake ratio as compared to morphine dependent rats, but spontaneous morphine intake ratio as compared to morphine dependent rats was gradually increased as in morphine dependent rats. (”

“As his tolerance escalated, he began injecting cocaine with morphine , also known as ‘‘speedball.’’”

“Moreover we have shown that cocaine , alcohol and nicotine significantly enhance (125)I-trace labeled morphine release from invertebrate ganglia and human white blood cells.”

“Medications and other substances that can increase serum CK levels include the following: • amphotericin B • ampicillin • aspirin • anticoagulants • dexamethasone • furosemide • morphine • statins • alcohol • cocaine.”

“Repeated injections of cocaine and morphine in laboratory rats cause a variety of molecular neuroadaptations in the cAMP signaling pathway in nucleus accumbens and ventral tegmental area.”

“Furthermore, invertebrate neural tissues incubated with ethanol, cocaine , or nicotine results in a statistically significant enhancement of labeled morphine release.”