Possible Interaction: Cocaine and Monoamine Oxidase Inhibitors

“Rationale and objectiveWhether monoamine oxidase inhibitors (MAOIs) can be used to suppress the reinforcing effect of cocaine remains unknown.”

“These findings suggest that monoamine oxidase inhibitors can modulate the discriminative stimulus effects of cocaine for at least 24 h, and may be useful for treatment of cocaine abuse.”

“The rise of the NA endogenous level 10 min after administration of a monamine oxidase inhibitor (ranylcypromine) was inhibited after cocaine treatment.”

“The norepinephrine-releasing effect of cocaine is increased by pretreatment with the monoamine oxidase inhibitor , pargyline, and decreased at lower temperatures.”

“SIR,-Previous work in our laboratory … shown that reserpine, desipramine and cocaine , when incubated in a medium containing nerve ending particles, 5-hydroxytryptamine (5-HT) and the monoamine oxidase inhibitor , pheniprazine, exerted an inhibitory effect on the uptake of ~ H T by these nerve ending particles (Segawa & Kuruma, 1968).”