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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ Cocaine significantly increased self-administration, subjective-effect ratings, and cardiovascular measures; modafinil at both doses (200 and 400 mg/day) markedly attenuated these effects.”
“ Modafinil has been reported to reduce cocaine use in a clinical sample of infrequent users (2 days/week), but the effects of modafinil on cocaine self-administration in the laboratory have not been studied.”
Smoked Cocaine Self-Administration is Decreased by Modafinil“ Cocaine withdrawal symptoms are associated with poor clinical outcome and are likely to be reversed by modafinil.”
“ Modafinil blunts the reinforcing as well as cardiovascular effects of cocaine.”
“Furthermore, modafinil has been shown to decrease cocaine self-administration.”
“Not only there is no evidence of pharmacokinetic interactions between modafinil and cocaine, but in addition cocaine induced euphoria and cardiovascular effects appear to be attenuated by modafinil.”
“Relative to placebo, modafinil robustly attenuated self-administration when cocaine was expensive ($10,$15/dose) and when there was no 'prime.'”
“These results suggest that modafinil may be most effective when combined with therapy emphasizing the large personal costs of using cocaine.”
“ Modafinil has reduced cocaine subjective effects and cocaine self-administration in human laboratory trials and has reduced cocaine use in cocaine dependent patients in some clinical trials.”
“Alhough the inhibition of dopamine reuptake is significantly less han that produced by cocaine, does this explain some interference ith the actions of cocaine in patients chronically treated by odafinil or one of its enantiomers?”
“In contrast, long-term administration of modafinil significantly decreased systemic exposure to cocaine during the first 180 minutes following intravenous cocaine administration.”
“JHW 007, but not R‐modafinil , partially inhibits the effects of cocaine on DA neurons.”
Atypical dopamine transporter inhibitors R-modafinil and JHW 007 differentially affect D2 autoreceptor neurotransmission and the firing rate of midbrain dopamine neurons
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