Possible Interaction: Cocaine and Mirtazapine

“Results: We found that chronic dosing with different doses of mirtazapine (30 and 60 mg/kg) decreased depression- and anxiety-like behaviors induced by different doses of cocaine (10, 20 and 40 mg/kg) during the 60-day cocaine withdrawal.”

“ Mirtazapine , an antagonist of the α2-adrenoceptor and the 5-HT2A/C and the 5-HT3 receptors has proven effective in reducing the cocaine , nicotine and methamphetamine behavioural effects in humans and animals.”

“Results: Mirtazapine decreased cocaine + nicotine-induced locomotor activity and induction and expression of locomotor sensitisation.”

“ Mirtazapine was dosed for 30 or 60 consecutive days prior to treatment with cocaine or during the extinction phase.”

“In addition, it showed that a dosing regimen of 30mg/Kg mirtazapine for 30 days managed to reduce cocaine toxicity.”

“We have reported elsewhere that 30mg/kg mirtazapine administered for 30 days during cocaine extinction significantly attenuated the induction and expression of cocaine-induced locomotor sensitization and decreased the duration of the cocaine-induced locomotor effect.”

“ Mirtazapine , an antagonist of the &agr;2‐adrenergic receptors, the 5‐HT2A/C, and the 5‐HT3 receptors, has proven effective in reducing behavioral effects induced by drugs like cocaine and methamphetamines in human and animal.”