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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Cocaine
drug:
Metyrosine
Research Papers that Mention the Interaction
“This effect of cocaine was inhibited by pretreatment with α-methyl-p-tyrosine , haloperidol, and physostigmine, but not with FLA-63, phenoxybenzamine and tetrabenazine.”
Possible role of dopamine in central effects of cocaine as measured by apomorphine gnawing test in mice“Even after pretreatment with α-methyl-p-tyrosine , which depletes the readily releasable pool of dopamine, cocaine was still capable of elevating dopamine levels.”
Cocaine Increases Dopamine Release by Mobilization of a Synapsin-Dependent Reserve Pool“ agr;‐Methyl‐p‐tyrosine methyl ester counteracted the effect of cocaine in blocking morphine tolerance and potentiated the tolerance development.”
“Abstract d-… and cocaine , which are postulated to release or block the reuptake of released dopamine at nerve terminals in the brain, produced only slight reductions … serum concentrations of prolactin in normal male rats or in rats in which the prolactin concentrations were elevated by pretreatment with α-methyltyrosine.”
“Pretreatment with α-methyl-p-tyrosine inhibits stereotyped behavior due to amphetamine, pemoline, and to some extent cocaine.”
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