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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
drug:
Metyrapone
Research Papers that Mention the Interaction
“ Metyrapone pretreatment dose-dependently decreased cocaine self-administration as demonstrated previously.”
“Specifically, research suggests that metyrapone (a corticosterone synthesis inhibitor) may reduce cocaine self-administration in rats via a nongenomic, extra-adrenal mechanism without altering plasma corticosterone.”
Role of GABA-active neurosteroids in the efficacy of metyrapone against cocaine addiction“Pretreatment with the P450 inhibitor, cimetidine (Cime, 50 mg/kg) or metyrapone (Mety, 40 mg/kg) abolished or significantly attenuated the effects of cocaine on TNF-α and CPK activity.”
“However, repeated injections (24, 16 and 2 h before tests) of metyrapone (50 mg/kg) with different doses of cocaine resulted in a rightward shift in the dose-response curve for cocaine and an increase in its ED50 value.”
“ Acute metyrapone treatment reduced the locomotor response to cocaine by about 50%, and this effect was reversed by corticosterone (20 mg/kg SC).”
“ Metyrapone treatment also similarly reduced the response to cocaine and corticosterone secretion in ad libitum-fed controls.”
“In another group of rats, pretreatment with metyrapone , which blocks the synthesis of corticosterone, resulted in dose-related decreases in ongoing cocaine self-administration.”
“However, rather than producing attenuation, metyrapone preadministration (3 100 mg/kg) markedly enhanced both the locomotor activating and stereotypy‐inducing actions of d‐amphetamine (dose equivalent to 2.5 mg/kg free base).”
“The clinically utilized corticosteroid synthesis inhibitor metyrapone attenuates the behavioural effects of cocaine in the rat.”
The corticosteroid synthesis inhibitor metyrapone markedly enhances the behavioural effects of d‐amphetamine
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