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Last Updated: 2 years ago

Possible Interaction: Cocaine and Methylphenidate

supplement:

Cocaine

Research Papers that Mention the Interaction

The present study was undertaken to investigate the likelihood of a toxic reaction in individuals who use cocaine while concurrently taking MPH.
Pharmacology Biochemistry and Behavior  •  2006  |  View Paper
Here we show in rats that exposure to MPH during pre-adolescence causes behavioral and neurobiological adaptations that endure into adulthood, and that are consistent with increased sensitivity to the aversive effects of cocaine.
Nature Neuroscience  •  2002  |  View Paper
Correspondingly, the subjective-effect profiles of MPH and cocaine showed striking parallels, with overall effects of MPH being rated more positively than those of cocaine.
Journal of psychoactive drugs  •  2016  |  View Paper
For this purpose we studied 62 participants (43 non-detoxified cocaine abusers and 19 controls) using positron emission tomography and [11C]raclopride (… dopamine) to measure dopamine increases induced by intravenous methylphenidate and in 24 of the cocaine abusers, we also compared dopamine increases when methylphenidate was … cocaine cue-…-video.
Molecular Psychiatry  •  2014  |  View Paper
The fact that methylphenidate induced craving only when given with the cocaine cues highlights the context dependency of methylphenidate's effects and suggests that its use for the treatment of ADHD subjects with co-morbid drug abuse should not increase craving.
NeuroImage  •  2008  |  View Paper
Despite similarity in psychopharmacological effects, the rewarding/reinforcing ability of MPH appears to be significantly lower than amphetamines and especially cocaine.
Journal of addictive diseases  •  2007  |  View Paper
A potential contributing factor to abuse is the reported similarities in pharmacodynamics and pharmacokinetics between MPD and cocaine.
Journal of the American Pharmaceutical Association  •  1999  |  View Paper
We found a significant association between cocaine and methylphenidate treatments and age progression in the prefrontal protein expression of brain derived neurotrophic factor (BDNF).
Behavioural Brain Research  •  2015  |  View Paper
Our previous results showed that methylphenidate treatment in adolescent SHR enhanced cocaine self-administration during adulthood, and alterations in DAT function in prefrontal cortex play a role in this response.
Biochemical pharmacology  •  2013  |  View Paper
We probed for strain and age differences in the sensitizing effects of methylphenidate using a cocaine challenge.
Behavioral and Brain Functions  •  2013  |  View Paper
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