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Last Updated: 2 years ago

Possible Interaction: Cocaine and Methacholine

supplement:

Cocaine

Research Papers that Mention the Interaction

In the smooth muscle of the rat vas deferens, 10(-5) M cocaine shifted the dose-response curve to norepinephrine to the left and enhanced the maximal contractions to norepinephrine and methacholine.
Journal of pharmacobio-dynamics  •  1990  |  View Paper
In the HEPES-buffered physiological solution containing 20 mM bicarbonate ion, cocaine not only increased the sensitivity to norepinephrine but enhanced the maximal contractions to norepinephrine and methacholine in the rat vas deferens.
Japanese journal of pharmacology  •  1989  |  View Paper
The ability of cocaine (10 μM) to potentiate the contractile responses of the epididymal half of the rat vas deferens to methacholine was reversed by prazosin.
We suggest that cocaine potentiated the responses to methacholine by stimulating, directly or indirectly, α1‐adrenoceptors.
The Journal of pharmacy and pharmacology  •  1985  |  View Paper
The sensitivity of the preparation to acetylcholine but not methacholine and carbachol was increased by cocaine.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica  •  1978  |  View Paper