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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
drug:
Methacholine
Research Papers that Mention the Interaction
“In the smooth muscle of the rat vas deferens, 10(-5) M cocaine shifted the dose-response curve to norepinephrine to the left and enhanced the maximal contractions to norepinephrine and methacholine.”
Propranolol blocks cocaine-induced potentiation of the contraction in the smooth muscle of the rat vas deferens.“In the HEPES-buffered physiological solution containing 20 mM bicarbonate ion, cocaine not only increased the sensitivity to norepinephrine but enhanced the maximal contractions to norepinephrine and methacholine in the rat vas deferens.”
“The ability of cocaine (10 μM) to potentiate the contractile responses of the epididymal half of the rat vas deferens to methacholine was reversed by prazosin.”
“We suggest that cocaine potentiated the responses to methacholine by stimulating, directly or indirectly, α1‐adrenoceptors.”
“The sensitivity of the preparation to acetylcholine but not methacholine and carbachol was increased by cocaine.”
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