Possible Interaction: Cocaine and Memantine

“Several cardiovascular responses, however, including peak and initial diastolic pressures following cocaine , were significantly greater during memantine maintenance, although these elevations were not clinically significant.”

“ Memantine maintenance was, however, associated with significant increases in some subjective effects of cocaine , including ratings of 'good drug effect', 'high', 'potency', 'quality', and street value.”

“Neither of the antagonists precipitated reinstatement of the preference induced by cocaine but memantine blocked the cocaine-primed reinstatement.”

“Conclusions: These results demonstrate that fairly high doses of memantine and morphine or cocaine have to be combined in order to observe an enhancement of the latter drugs’ potentiation of brain stimulation reward.”

“ Memantine prevented acquisition and expression of the place preference produced by cocaine , while ACPC prevented only acquisition effect.”

“Of interest, pretreatment with memantine at 10 mg kg(-1), which alone had no effect on corticosterone levels, caused a greater elevation of corticosterone levels in combination with 'binge' cocaine than acute 'binge' cocaine alone, indicating that memantine does not attenuate 'binge' cocaine-stimulated hypothalamic-pituitary-adrenal activity.”

“Additionally, memantine was associated with increased subjective effects of alcohol, cocaine , and nicotine.”