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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
drug:
Medetomidine
Research Papers that Mention the Interaction
“ Medetomidine induced significant respiratory depression with decrease in RR and TV in freely moving animals while cocaine increased TV, RR and minute ventilation (MV) with concomitant increase in heart rate when compared with time matched values from saline-treated animals.”
Combined cardiopulmonary assessments with implantable telemetry device in conscious freely moving cynomolgus monkeys.“The combination of medetomidine (25 micrograms/kg SC) with cocaine (10-20 mg/kg IP) produced potentiation of antinociception in the tailflick test both in intact and spinal rats.”
“The results indicate that at the supraspinal level there is an additive antinociceptive interaction between cocaine and medetomidine , whereas at the spinal level cocaine potentiates the medetomidine-induced antinociception independent of supraspinal mechanisms.”
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