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Last Updated: 2 years ago

Possible Interaction: Cocaine and Mecamylamine

supplement:

Cocaine

Research Papers that Mention the Interaction

Previously, we showed that the nonspecific nicotinic antagonist mecamylamine significantly reduces cocaine self‐administration in rats.
European journal of pharmacology  •  2019  |  View Paper
Mecamylamine treatment significantly attenuated expression of cocaine behavioral sensitization on both withdrawal days 7 and 14.
Behavioural Brain Research  •  2014  |  View Paper
ResultsControl rats and rats that received a low dose of MEC (7 μg/infusion) with cocaine increased their average hourly intake over 5 days of 6 h per day cocaine access.
When MEC was removed, this group showed an escalation in cocaine self-administration.
Psychopharmacology  •  2007  |  View Paper
Recently, systemic administration of the nicotinic receptor antagonist mecamylamine was shown to block the induction of long-term locomotor sensitization to cocaine.
Behavioural Brain Research  •  2006  |  View Paper
Pretreatment with mecamylamine (0.3-3 mg/kg) and MRZ 2/621 (0.3-10 mg/kg) produced dose-dependent suppression of both cocaine and nicotine self-administration.
European Neuropsychopharmacology  •  2005  |  View Paper
Coadministration of mecamylamine during pretreatment with nicotine, amphetamine, or cocaine prevented the development of this long-term hyperreactivity of nucleus accumbens dopamine neurons.
The Journal of Neuroscience  •  2002  |  View Paper
Mecamylamine , compared to saline, significantly (P<.05) reduced the number of cocaine infusions per session with each of these doses.
Physiology & Behavior  •  2000  |  View Paper