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“ResultsControl rats and rats that received a low dose of MEC (7 μg/infusion) with cocaine increased their average hourly intake over 5 days of 6 h per day cocaine access.”
“When MEC was removed, this group showed an escalation in cocaine self-administration.”
“Recently, systemic administration of the nicotinic receptor antagonist mecamylamine was shown to block the induction of long-term locomotor sensitization to cocaine.”
“Pretreatment with mecamylamine (0.3-3 mg/kg) and MRZ 2/621 (0.3-10 mg/kg) produced dose-dependent suppression of both cocaine and nicotine self-administration.”
European Neuropsychopharmacology • 2005 | View Paper
“Coadministration of mecamylamine during pretreatment with nicotine, amphetamine, or cocaine prevented the development of this long-term hyperreactivity of nucleus accumbens dopamine neurons.”