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Last Updated: 3 months ago

Possible Interaction: Cocaine and Mazindol



Research Papers that Mention the Interaction

Mazindol is a catecholamine reuptake inhibitor that blocks binding of cocaine at the dopamine reuptake site.
There were significant interactions between the effects of cocaine and mazindol on heart rate and blood pressure, with combinations producing significantly large and more sustained increases compared with cocaine alone.
The Journal of pharmacology and experimental therapeutics  •  1993  |  View Paper
The present results suggest that complex interactions reported between cocaine and mazindol in inhibiting dopamine transport are beyond the level of ligand recognition.
The Journal of pharmacology and experimental therapeutics  •  1997  |  View Paper
This transport is blocked … psychostimulant drugs cocaine , l- and d-amphetamine, and phenyclidine), neurotoxins (6-hydroxydopamine and N-methyl-4-phenylpyridine (MPP))+), neurotransmitters (epinephrine, …, gamma-aminobutyric acid, and serotonin), antidepressants (amitriptyline, bupropion, desipramine, mazindol, nomifensine, and nortriptyline), and various uptake inhibitors ( mazindol , GBR 12783, GBR 12909, and amfonelic acid).
Molecular pharmacology  •  1992  |  View Paper
Previous exposure to cocaine significantly affected locomotor activity and stereotopy-like behavior produced by cocaine, mazindol , RTI-55, and GBR12909.
Pharmacology Biochemistry and Behavior  •  1996  |  View Paper
In contrast, mazindol and nomifensine were found to bind to separate interactive sites when individually paired with cocaine.
Journal of neurochemistry  •  1994  |  View Paper
We have shown previously that the reinforcing effects of cocaine can be correlated with drug binding to the mazindol and GBR 12935 binding sites on the dopamine transporter.
The Journal of pharmacology and experimental therapeutics  •  1989  |  View Paper