supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Cocaine
supplement:
Magnesium Chloride
Research Papers that Mention the Interaction
“Following chronic 0.5 mg/kg cocaine for 15 days, a dose of 125 mg/kg acutely administered MgCl2 prevented the disruptive effects of chronic cocaine on mouse aggression.”
Magnesium alters the potency of cocaine and haloperidol on mouse aggression“Attenuation of the rate-decreasing effects of the highest dose of cocaine (30 mg/kg) also were observed after pretreatment with dizocilpine and magnesium chloride.”
“In addition, dizocilpine and magnesium chloride each attenuated the discriminative stimulus effects of higher doses of cocaine.”
“Selected doses of dizocilpine, magnesium chloride , and phencyclidine given in combination with 1 mg/kg cocaine produced more cocaine-appropriate responses than this dose of cocaine alone.”
“Acute and multiple injections of MgCl2 (15-250 mg/kg) produced dose-dependent reductions in responding maintained by cocaine (0.1-2 mg/kg/infusion).”
“Doses of 30 and 125 mg/kg MgCl2 reduced responding maintained by doses of cocaine that were below the training dose of 0.75 mg/kg/infusion.”
“ MgCl2 in a dose of 250 mg/kg markedly suppressed responding maintained by each dose of cocaine.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback