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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Cocaine
Research Papers that Mention the Interaction
“Patients' craving for cocaine was found to decrease significantly after the administration of m-CPP.”
Craving for cocaine in addicted users. Role of serotonergic mechanisms.“Additivity was observed during combined exposure to low concentrations of cocaine and mCPP as well as during combined exposure to MDA with cocaine or mCPP.”
“The PRL response to m-CPP was significantly diminished in cocaine patients compared to controls.”
“ mCPP or fenfluramine significantly increased the expression of hypothalamic pro-opiomelanocortin and cocaine- and amphetamine-regulated transcript genes while having no significant effects on the expression of hypothalamic neuropeptide Y, agouti- related protein, and ghrelin genes.”
A negative feedback system between brain serotonin systems and plasma active ghrelin levels in mice.“R(-)-DOI, mCPP , and MK212 reduced the threshold of meprylcaine or cocaine with less extent than the reduction of lidocaine threshold.”
“The stimulus effects of cocaine were attenuated by mCPP at doses that reduced response rates.”
“In contrast, … either mCPP (0.25-2 mg/kg) or MK 212 (…-2 mg/kg) plus a dose of cocaine (5 mg/kg) that produced > 85% cocaine-appropriate responding when given alone partially antagonized cocaine; … (1 mg/kg) also produced a rightward shift in the cocaine dose-response curve.”
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