Possible Interaction: Cocaine and Lorcaserin

“Mounting evidence from preclinical and clinical studies suggests that lorcaserin might also be effective at reducing the abuse‐related effects of drugs with different pharmacological mechanisms (e.g., cocaine , heroin, ethanol, and nicotine).”

“This effectiveness of 5-HT2C agonists to attenuate cocaine-induced enhancement of NAc DA signaling suggested that lorcaserin or other 5-HT2C agonists might also be useful to block abuse-related behavioral effects of cocaine and be useful for treating CUD [3, 5].”

“Some positive subjective effects of cocaine were enhanced by lorcaserin , and it delayed intravenous choices and decreased craving under some conditions.”

“Agonists at serotonin (5-HT)2C receptors, particularly lorcaserin , are being considered as pharmacotherapies for abuse of a variety of drugs, including cocaine and opioids.”

“Two such drugs, lorcaserin (Belviq; a drug with serotonin [5-HT]2C receptor agonist properties) and buspirone (Buspar; a drug with 5-HT1A receptor partial agonist and dopamine D3/D4 receptor antagonist properties) can produce modest decreases in cocaine self-administration in rhesus monkeys.”

“ Lorcaserin decreased cocaine and MDPV self-administration with equal potency.”

“ Lorcaserin decreases cocaine self-administration in rats and monkeys.”

“ Lorcaserin (3.2 mg/kg) significantly decreased the final ratio completed (i.e., decreased break point) in monkeys responding … the PR schedule and reduced the reinstatement of responding for drug-associated stimuli following a noncontingent infusion of cocaine ; these effects did not appear to … when lorcaserin was administered daily.”

“The current study investigated the effectiveness of lorcaserin to reduce self-administration of either cocaine or methamphetamine and cocaine-induced reinstatement of extinguished responding.”

“The serotonin2C [5-hydroxytryptamine2C (5-HT2C)] receptor agonist lorcaserin decreases some abuse-related effects of cocaine in monkeys and might be useful for treating stimulant abuse.”

“Together, these results indicate that lorcaserin might be effective in reducing cocaine and methamphetamine abuse and cocaine relapse at least in some individuals.”

“These studies characterized the pharmacokinetic and behavioral profiles of lorcaserin (intragastric administration) and determined the effectiveness of lorcaserin to alter discriminative stimulus and reinforcing effects of cocaine (intravenous administration) in rhesus monkeys.”

“Together, these results show that lorcaserin attenuates the discriminative stimulus effects of cocaine after acute administration and the reinforcing effects of cocaine after acute and repeated administration, consistent with the view that it might have utility in treating cocaine abuse.”

“When administered acutely, lorcaserin dose-dependently decreased the rate at which monkeys responded for infusions of cocaine.”

“ Lorcaserin also reduces reinstatement of cocaine-seeking behaviour in response to priming injections of cocaine and/or reintroduction of cocaine-associated cues.”

“We find that lorcaserin dose-dependently decreases cocaine self-administration on progressive and fixed ratio schedules of reinforcement.”

“For the cocaine vs. money choice procedure, there was a significant interaction between choice (cocaine vs. money) and lorcaserin.”