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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ Lidocaine was used as an internal control for the local anesthetic property of cocaine (11).”
Mechanism of Cocaine-Induced Hyperthermia in Humans“Patients who received lidocaine plus cocaine reported a mean score of 3.33 for over-all discomfort of cystoscopy.”
“The profile of action of cocaine was significantly different from that produced by lidocaine or placebo whereas the effects of lidocaine were indistinguishable from those of placebo.”
“These data suggest cross-sensitization between the two local anesthetics lidocaine and cocaine , even though lidocaine does not possess the psychomotor stimulant effects of cocaine.”
“ Lidocaine is an amide local anesthetic that may have addictive effects, in the presence of cocaine , which may lower the seizure threshold.”
“Eight drugs were considered candidates for potential interference with cocaine; lidocaine and droperidol were found to interfere in actual patients' samples.”
“During cue-induced reinstatement tests preceded by a cocaine priming injection, 100 µg lidocaine significantly decreased both drug-seeking behavior and the number of infusion-paired light deliveries earned.”
Stimulus-response functions of the lateral dorsal striatum and regulation of behavior studied in a cocaine maintenance/cue reinstatement model in rats“As expected, the free base of lidocaine was more potent than its salt.”
“Seizure susceptibility of procaine and lidocaine increased after the end of two days of treatment with a subconvulsive dose of cocaine.”
“However, rats treated with cocaine and lidocaine in combination had significantly greater locomotor activity initially than animals treated with cocaine alone.”
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