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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
drug:
Ketoconazole
Research Papers that Mention the Interaction
“To examine whether attenuation of HPA function reduces the effects of cocaine in humans, one female and seven male 'crack' cocaine abusers were pretreated with three doses of ketoconazole (0, 600, 1200 mg), an inhibitor of adrenocorticoid biosynthesis, 1 h before receiving cocaine.”
Ketoconazole attenuates the cortisol response but not the subjective effects of smoked cocaine in humans“Rationale: Ketoconazole , an inhibitor of corticosterone synthesis, has been reported to decrease the self-administration of low doses of cocaine and prevent stress-induced reinstatement of cocaine-reinforced behavior in rats.”
“Results: Pretreatment with ketoconazole decreased both the rate of acquisition of cocaine self-administration and the percentage of rats meeting the acquisition criterion but only under food-restricted conditions.”
Effects of ketoconazole on the acquisition of intravenous cocaine self-administration under different feeding conditions in rats“Given subacutely (24, 16 and 1 h before tests), ketoconazole (50 mg/kg) produced a left-ward shift in the dose-response curve for cocaine and decreased its ED50 value.”
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