Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago

Possible Interaction: Cocaine and Ketamine

supplement:

Cocaine

Research Papers that Mention the Interaction

Moreover, ketamine reduced craving for and self‐administration of cocaine in non‐treatment seeking cocaine users.
Neuropharmacology  •  2018  |  View Paper
The conclusions are that ketamine dependence is linked with effects that this complex drug has in common with not only cocaine and amphetamine but also with opiates, alcohol and cannabis, as well as the psychological attractions of its distinctive psychedelic properties.
Journal of psychoactive drugs  •  2001  |  View Paper
This study showed that fetal exposure to ketamine and cocaine in combination was more teratogenic than each drug alone in CF-1 mice.
Teratology  •  2000  |  View Paper
In particular, poly-drug users who consume ketamine in combination with heroin or cocaine presenting to the ED represent a specific target for targeted prevention projects on non-lethal overdoses and suicide attempts.
Annali dell'Istituto superiore di sanita  •  2019  |  View Paper
Using an established laboratory model aimed at evaluating … now vs money later, we found that ketamine, … cocaine self-administration by 67% relative to baseline at greater than 24 h post-infusion, the most … human cocaine users and the first to involve mechanisms other than stimulant or dopamine agonist effects.
Molecular Psychiatry  •  2017  |  View Paper
Collectively, we demonstrate that in the absence of physical or psychological stress, adolescent ketamine exposure increases later life preference for the rewarding properties of sucrose and cocaine in a sex- and age-specific manner.
Neuropsychopharmacology  •  2020  |  View Paper
Clinical studies have shown ketamine to reduce cocaine and heroin cravings.
Neurotoxicity Research  •  2017  |  View Paper
For … COC (30 mg/kg) or MA (4 mg/kg) groups of mice simultaneously co-treated with KT , the psychostimulant-induced hyperlocomotion was suppressed by the high dose KT, and the psychostimulant-induced behavioral alterations in the above tests were reversed by both low and high doses of KT.
BMC Neuroscience  •  2005  |  View Paper
Protein blot analysis showed that ketamine-induced P-450 2B1/2 proteins also decreased in a time-dependent manner in 4 d. In hepatotoxicity …/kg ketamine for 4 d. Treatment of ICR mice with 120 mg/kg cocaine produced a 17% mortality, whereas the same dose of cocaine … ketamine.
Treatment … cocaine produced a 76-fold increase in serum alanine aminotransferase …-fold rise in mice pretreated with 80 mg/kg ketamine for 4 d. The present study shows that ketamine induces the expression of multiple … rat liver microsomes and increases CCl4-induced liver toxicity and cocaine-mediated acute toxicity.
Journal of toxicology and environmental health. Part A  •  2005  |  View Paper
In conclusion, this study demonstrates that KET pretreatment potentiates the hepatotoxicity of COC as revealed by an array of biochemical and morphological markers most probably due to increase in COC oxidative metabolism.
Serum ALT and AST were significantly elevated with the combined KET and COC treatment versus all other treatments.
The abuse of KET with COC is currently popular among young abusers therefore; this study was conducted to investigate the possible potentiation of COC-mediated hepatotoxicity (CMH) by KET.
The results demonstrate that KET pretreatment potentiated the hepatotoxicity of COC.
While COC alone resulted in focal inflammatory cell infiltration, COC administration after KET pretreatment produced sub-massive hepatic necrosis.
Toxicology letters  •  2004  |  View Paper
Show More