Possible Interaction: Cocaine and Isradipine

“Despite preclinical studies suggesting that isradipine may antagonize the abuse liability of cocaine , pretreatment with sustained-release isradipine did not reduce euphoric mood in cocaine-using volunteers.”

“This double-blind, within-subject, crossover laboratory … determined whether maximal dose-loading with isradipine could antagonize effects of cocaine in 12 cocaine-dependent research volunteers administered intravenous cocaine doses (0, 0.325, and 0.65 mg/kg) on different days after 5 days of treatment with isradipine or placebo.”

“ Isradipine alone attenuated the systolic blood pressure response to cocaine.”

“ Isradipine , a dihydropyridine-class calcium channel antagonist, reduces the rewarding effects of psychostimulants such as cocaine and d-amphetamine, presumably by antagonizing these central DA pathways.”

“This is the first demonstration that any medication, including isradipine , can prevent the ischemic effects of cocaine on brain blood flow.”

“These results suggest that isradipine antagonizes the rewarding properties of cocaine , possibly by inhibiting those dopaminergic systems related to reward mechanisms.”

“Here, we asked whether ISR&NTX would lose its ability to reduce the reinforcing effects of cocaine and alcohol when given daily.”

“In another experiment, isradipine (3.0 mg/kg) persistently blocked the rate-enhancing effects of cocaine (5.0 mg/kg) across 5 consecutive days.”

“Using rats pressing for rewarding electrical intracranial stimulation of the medial forebrain bundle, it was found that a single administration of isradipine blocked the rate-enhancing effects of cocaine (5.0 mg/kg) at doses of 3.0 and 10.0 mg/kg.”

“Pretreatment of mice with isradipine (1.0-3.0 mg/kg, SC) or nimodipine (5-20 mg/kg, SC) inhibited in a dose-related manner self-administration both of cocaine and morphine contingent upon a nose-poke response.”