supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Cocaine
drug:
Indomethacin
Research Papers that Mention the Interaction
“ Cocaine and indomethacin may act synergistically to adversely affect renal, cardiovascular, and platelet function.”
Cocaine and indomethacin: fetal anuria, neonatal edema, and gastrointestinal bleeding.“The cyclooxygenase-1 inhibitor, indomethacin , also failed to inhibit relaxations induced by cocaine HCl (P>0.05).”
Cocaine-induced relaxation of isolated rat aortic rings and mechanisms of action: possible relation to cocaine-induced aortic dissection and hypotension.“However, haloperidol, indomethacin , verapamil and excess [Mg++]0 (4.8 x 10(-3) M) as well as removal of [Ca++]0 completely prevented vasospasms induced by COC.”
“In contrast, coadministration of either tetrodotoxin (Na+ channel blocker), charybdotoxin (K+ channel blocker), or quinacrine (phospholipase A2 inhibitor), or pretreatment with indomethacin (cyclooxygenase inhibitor) attenuated vasoconstriction induced by cocaine.”
“Fractional NE overflow was significantly increased in SHR preparations in the presence of the combination of cocaine and indomethacin , whereas it remained unaltered in WKY preparations.”
“The combination of indomethacin and cocaine resulted in a significant enhancement of perfusion pressure responses to periarterial nerve stimulation in both strains that was significantly greater than that produced by either drug alone.”
“ Indomethacin (5 microM), SKF-525A, and chloramphenicol also failed to block vasoconstriction induced by cocaine.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback