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Last Updated: 2 years ago

Possible Interaction: Cocaine and Indomethacin

supplement:

Cocaine

Research Papers that Mention the Interaction

Cocaine and indomethacin may act synergistically to adversely affect renal, cardiovascular, and platelet function.
Obstetrics and gynecology  •  1991  |  View Paper
The cyclooxygenase-1 inhibitor, indomethacin , also failed to inhibit relaxations induced by cocaine HCl (P>0.05).
European journal of pharmacology  •  2004  |  View Paper
However, haloperidol, indomethacin , verapamil and excess [Mg++]0 (4.8 x 10(-3) M) as well as removal of [Ca++]0 completely prevented vasospasms induced by COC.
The Journal of pharmacology and experimental therapeutics  •  1994  |  View Paper
In contrast, coadministration of either tetrodotoxin (Na+ channel blocker), charybdotoxin (K+ channel blocker), or quinacrine (phospholipase A2 inhibitor), or pretreatment with indomethacin (cyclooxygenase inhibitor) attenuated vasoconstriction induced by cocaine.
European journal of pharmacology  •  1993  |  View Paper
Fractional NE overflow was significantly increased in SHR preparations in the presence of the combination of cocaine and indomethacin , whereas it remained unaltered in WKY preparations.
The combination of indomethacin and cocaine resulted in a significant enhancement of perfusion pressure responses to periarterial nerve stimulation in both strains that was significantly greater than that produced by either drug alone.
The Journal of pharmacology and experimental therapeutics  •  1991  |  View Paper
Indomethacin (5 microM), SKF-525A, and chloramphenicol also failed to block vasoconstriction induced by cocaine.
Biochemical pharmacology  •  1989  |  View Paper