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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
drug:
Imipramine
Research Papers that Mention the Interaction
“ Imipramine (10–50 mg/kg) produced a dose-related decrease in cocaine self-administration.”
The effects of stimulants and depressants on cocaine self-administration behavior in the Rhesus monkey“The results indicate that chronic imipramine facilitates mesolimbic dopamine neurotransmission by potentiating the mechanism which is thought to mediate the rewarding effects of cocaine.”
“In addition, several other effects of cocaine (e.g., bradycardia, rear-limb dyskinesia) were potentiated by imipramine treatment.”
“This uptake is blocked by both cocaine and imipramine.”
“ Imipramine inhibited the in vitro uptake of noradrenaline‐3H in rat vas deferens as did cocaine , desmethylimipramine and dexchlorpheniramine.”
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