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Last Updated: 2 years ago

Possible Interaction: Cocaine and Ifenprodil

supplement:

Cocaine

Research Papers that Mention the Interaction

Administration of the GluN2A‐ and GluN2B‐NMDA receptor antagonists, NVP‐AAM077 and ifenprodil , respectively, immediately following recall abrogated an established cocaine place preference, while preventing the activation of GSK3β in the amygdala, nucleus accumbens, and hippocampus during cocaine memory reactivation.
Journal of neurochemistry  •  2019  |  View Paper
Pretreatment of Kal7KO mice with a low dose of ifenprodil , a selective GluN2B antagonist, eliminated their enhanced locomotor response to cocaine , revealing an important role for GluN2B in this behavior.
BMC Neuroscience  •  2017  |  View Paper
Ifenprodil neither increased locomotor activity nor augmented the stimulatory effect of cocaine; however, ifenprodil attenuated the stimulant effects of cocaine at doses 0.5 log unit lower than those required to reduce spontaneous activity when given alone.
In contrast to cocaine, ifenprodil did not produce convulsions or signs of proconvulsant activity, and ifenprodil reduced the percentage of mice convulsing in the presence of cocaine.
In this study, the ability of ifenprodil to mimic, enhance or block behavioral and toxic effects of cocaine was evaluated.
Behavioural pharmacology  •  1995  |  View Paper