Possible Interaction: Cocaine and Idazoxan

“In the present study, the noradrenaline reuptake inhibitor cocaine has been shown to overcome the inhibitory effects of idazoxan , a selective alpha-2 receptor antagonist, but not phentolamine, a non-selective alpha receptor antagonist, on eating following injection of noradrenaline into the rat hypothalamic paraventricular nucleus.”

“In contrast, COC animals were significantly more sensitive than controls to the effects of IDZ on omission errors and nontrials.”

“2 Yohimbine and idazoxan (0.01 to 1 μm) increased fractional evoked overflow of tritium by up to 2 fold; in the presence of these drugs, cocaine (10 μm) produced an increase in both tissues (up to 3.5 fold over control).”

“In the presence of cocaine , in proximal segments, antagonism of EPI by prazosin was reduced, whereas in distal segments, antagonism by idazoxan and the inhibitory effect of a reduction in calcium ion concentration were reduced.”

“For a given frequency, rauwolscine and idazoxan enhanced the evoked overflow to a greater extent in the presence than in the absence of cocaine.”

“ Idazoxan , an α2-adrenergic receptor antagonist, significantly enhanced the ASR, but less enhancement was noted with increasing doses of prenatal cocaine.”