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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Reductions in ICSS thresholds following cocaine injection were greater in HiS rats than in LoS rats, suggesting that the reward-enhancing effects of cocaine are greater in the drug-vulnerable HiS than LoS rats.”
Cocaine-induced reward enhancement measured with intracranial self-stimulation in rats bred for low versus high saccharin intake“ L-histidine (400 mg/kg), a precursor of histamine, significantly enhanced the discriminative stimulus effects of cocaine and methamphetamine.”
“8 Administration of cocaine increases HA levels and HA metabolic enzyme activity in the NA and striatum and L-histidine inhibits cocaine induced activity.”
“The pretreatment with l‐histidine (350 and 700 mg/kg) inhibited the cocaine (20 mg/kg)‐induced increase of wheel‐running activity in a dose‐dependent manner.”
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