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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“However, the overall effect of cocaine on muscle contracture in the presence of 1% halothane was insignificant in both groups.”
Effect of cocaine on the contracture response to 1% halothane in patients undergoing diagnostic muscle biopsy for malignant hyperthermia.“5 Experimental animal studies have shown that cocaine potentiates the arrhythmic effects of halothane and adrenaline combinations.6 The increased carbon dioxide levels which may be associated with spontaneous ventilation could further increase the risk of arrhythmias.”
“Antagonism of the pressor response to cocaine by halothane was significantly greater than that by pentobarbital.”
“Pentobarbital or halothane anesthesia attenuated the pressor and tachycardiac effects of 3 mg/kg of cocaine.”
The role of central and autonomic neural mechanisms in the cardiovascular effects of cocaine in conscious squirrel monkeys.“5 Experimental animal studies have shown that cocaine potentiates the arrhythmic effects of halothane and adrenaline combinations.6 The increased carbon dioxide levels which may be associated with spontaneous ventilation could further increase the risk of arrhythmias.”
“ Halothane MAC 24 hours following a single administration of either 2 mg/kg or 4 mg/kg of cocaine or after 10 daily doses of 4 mg/kg of cocaine was near control MAC.”
“These data support the speculation that increased central nervous system catecholamine concentrations, as may occur with cocaine , increase halothane anesthetic requirements.”
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