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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Cocaine
drug:
Haloperidol
Research Papers that Mention the Interaction
“ Haloperidol (8 mg) has a small and limited effect on the subjective response to cocaine when given 20 min before cocaine.”
Effects of intravenous cocaine are partially attenuated by haloperidol“This effect of cocaine was inhibited by pretreatment with α-methyl-p-tyrosine, haloperidol , and physostigmine, but not with FLA-63, phenoxybenzamine and tetrabenazine.”
“Coincubation of cocaine with haloperidol or ditolylguanidine abolished or reduced cocaine-induced endothelin release.”
“Diazepam (5 mg/kg) but not haloperidol (0.16 or 0.64 mg/kg) significantly antagonized the discriminative stimuli produced by pentylenetetrazol and cocaine.”
“Given in combination, haloperidol reversed the effects of cocaine on the levels of NE, DA and 5-HT.”
“ Cocaine and its analog RTI-55 [2 beta-carbomethoxy-3 beta-(4-iodophenyl-) tropane] inhibited the binding of haloperidol to placental membranes with appreciable potency.”
“Using this new methodology, we found that cocaine , a psychostimulant, and haloperidol , a sedation-producing antipsychotic, exert differential effects on DARPP-32 phosphorylation in the two neuronal populations that can explain their opposing behavioral effects.”
Cell type–specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs“Antagonism of cocaine's error-increasing effects by haloperidol was only evident at one dose of cocaine (0.032 mg/kg/infusion), and was more complete in the performance components than in the acquisition components.”
“Together, these data show the limited suitability of haloperidol for selectively antagonizing cocaine self-administration in the context of a multiple schedule involving transition behavior, and show the lack of uniform antagonism across operant behaviors.”
“ Haloperidol (a dopamine-receptor antagonist) attenuated the hyperlocomotion induced by the combination of cocaine or methamphetamine plus morphine.”
“These findings indicate that withdrawal from long-term treatment with typical neuroleptic drugs such as haloperidol (but not the atypical compound ziprasidone) may enhance some behavioral effects of cocaine in mice which have been related to drug dependence in humans.”
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