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Last Updated: 2 years ago

Possible Interaction: Cocaine and Guanfacine

supplement:

Cocaine

Research Papers that Mention the Interaction

Discounting was associated with cocaine self-administration in vehicle males (R2 = −0.4, P < 0.05) and self-administration was reduced by guanfacine treatment (0.3 mg/kg).
Guanfacine significantly decreased cocaine sensitivity in both sexes.
Psychopharmacology  •  2018  |  View Paper
These animal studies suggest that guanfacine may have therapeutic potential for treating impairments of executive function that are associated with the abuse of cocaine.
administration of cocaine (4.0mg/kg) was associated with impairments in accuracy at long delay intervals, an effect that was attenuated by guanfacine (0.4mg/kg).
Pharmacology Biochemistry and Behavior  •  2014  |  View Paper