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Possible Interaction: Cocaine and Guanethidine

supplement:

Cocaine

Research Papers that Mention the Interaction

The effect of cocaine , but not of atropine and homatropine, was prevented by pretreatment with guanethidine.
Investigative ophthalmology & visual science  •  1977  |  View Paper
Bretylium and cocaine possess the property of reducing the depletion of noradrenaline in rat hearts and spleens produced either by guanethidine or by reserpine.
The Journal of pharmacy and pharmacology  •  1962  |  View Paper
When co-incubated with guanethidine (3 &mgr;M), the twitch was reduced to 24% ± 4% of control and was reversed to 77% ± 7% after 1 h. Cocaine (30 &mgr;M) inhibited the twitch response to 53% ± 8%, which was fully reversed by 1 h of washing.
Anesthesia and analgesia  •  2002  |  View Paper
The evoked efflux was significantly augmented by cocaine or DG‐5128 and was inhibited by guanethidine or tetrodotoxin.
The Journal of physiology  •  1989  |  View Paper
These effects of guanethidine were prevented by pretreatment with cocaine or imipramine.
British journal of pharmacology  •  1984  |  View Paper
Cocaine (5 mg/kg) antagonized the inhibition produced by a low dose of guanethidine (2.5 mg/kg) by about 80% but was unable to antagonize that produced by high doses (10 mg/kg or more).
In the presence of guanethidine, cocaine (10 µg/ml) only partially restored the norepinephrine output (20%) but almost fully restored the increase in peripheral resistance (60-100%).
Prior perfusion with cocaine only slightly antagonized the inhibitory effect of guanethidine.
The Journal of pharmacology and experimental therapeutics  •  1969  |  View Paper
3 Cocaine , in a concentration which produced the same effect on noradrenaline uptake as the concentration of dexamphetamine used, was also effective in reversing the adrenergic neurone blocking actions of guanethidine.
British journal of pharmacology  •  1969  |  View Paper
Both cocaine and protniptyline antagonize the response to guanethidine partially, but not completely.
The time-response curve for guanethidine becomes flattened in the presence of high doses of either cocaine or protniptyline.
The Journal of pharmacology and experimental therapeutics  •  1969  |  View Paper
Treatment with cocaine , imipramine or reserpine reduced the sensitivity to bretylium and guanethidine of the spinal cat.
British journal of pharmacology and chemotherapy  •  1963  |  View Paper
Drugs like cocaine , reserpine, imipramine, chlorpromazine, guanethidine a. s. o. also inhibit the uptake of NE by tissues.
Acta Neurovegetativa  •  2005  |  View Paper
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