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Investigative ophthalmology & visual science • 1977 | View Paper
“Bretylium and cocaine possess the property of reducing the depletion of noradrenaline in rat hearts and spleens produced either by guanethidine or by reserpine.”
The Journal of pharmacy and pharmacology • 1962 | View Paper
“When co-incubated with guanethidine (3 &mgr;M), the twitch was reduced to 24% ± 4% of control and was reversed to 77% ± 7% after 1 h. Cocaine (30 &mgr;M) inhibited the twitch response to 53% ± 8%, which was fully reversed by 1 h of washing.”
British journal of pharmacology • 1984 | View Paper
“ Cocaine (5 mg/kg) antagonized the inhibition produced by a low dose of guanethidine (2.5 mg/kg) by about 80% but was unable to antagonize that produced by high doses (10 mg/kg or more).”
“In the presence of guanethidine, cocaine (10 µg/ml) only partially restored the norepinephrine output (20%) but almost fully restored the increase in peripheral resistance (60-100%).”
“Prior perfusion with cocaine only slightly antagonized the inhibitory effect of guanethidine.”
The Journal of pharmacology and experimental therapeutics • 1969 | View Paper
“3 Cocaine , in a concentration which produced the same effect on noradrenaline uptake as the concentration of dexamphetamine used, was also effective in reversing the adrenergic neurone blocking actions of guanethidine.”