Possible Interaction: Cocaine and Gaba Agents

“BACKGROUND GABAergic medications appear to reduce the reinforcing effects of cocaine by attenuating cocaine-induced dopamine release.”

“ Cocaine and MPH sub‐chronic administration altered paired‐pulse and spontaneous GABAergic input differently.”

“We find that cocaine selectively potentiates AMPA receptor-mediated EPSCs in LHb neurons that send axons to the rostromedial tegmental nucleus, a GABAergic structure that modulates the activity of midbrain DA neurons.”

“Recent studies indicate that GABAergic ligands modulate abuse-related effects of cocaine.”

“Thus, one mechanism by which prenatal cocaine exposure exerts deleterious effects on cerebral cortical development may be by decreasing GABAergic neuronal migration from the ganglionic eminence to the cerebral wall.”

“We found that recurrent, transplacental exposure of mouse embryos to cocaine from embryonic day 8 to 15 decreases tangential neuronal migration and results in deficits in GABAergic neuronal populations in the embryonic cerebral wall.”

“These findings suggest that nicotine and cocaine differentially activate circuitry in which mu receptors are situated, especially GABAergic elements.”

“Overall, it can be concluded that cocaine in higher concentrations directly affects development of GABAergic neurons in vitro.”

“In all progeny of rabbits exposed … 3 or 4 mg/kg of cocaine during pregnancy, there was a significant change in the structure of … dendrites, a significant increase in the number of dendrites of GABAergic neurons which were parvalbumin immunoreactive, and a significant reduction in D1/G protein coupling.”