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Possible Interaction: Cocaine and Flupenthixol

supplement:

Cocaine

Research Papers that Mention the Interaction

The effects of methylphenidate and cocaine on responding for social play, but not their play-suppressant effects, were blocked by pretreatment with the dopamine receptor antagonist α-flupenthixol.
Neuropsychopharmacology  •  2016  |  View Paper
Infusion … α-flupenthixol into the ventral nucleus accumbens (NAcc) shell inhibited the acquisition of cocaine self-administration, reduced responding for the drug … FR-1 and PR schedules of reinforcement, and caused a downward shift of the dose–response curve of cocaine self-administration under an …-1 schedule of reinforcement.
Neuropsychopharmacology  •  2012  |  View Paper
α-Flupenthixol increased cocaine but not sucrose intake under an FR-1 schedule of reinforcement.
Psychopharmacology  •  2011  |  View Paper
α-Flupenthixol blocked the development of both cocaine- and morphine-induced CPP but did not affect the development of sensitization to either drug.
Psychopharmacology  •  2010  |  View Paper
The priming effects of cocaine were antagonized by clonidine and flupenthixol.
Journal of Pharmacology and Experimental Therapeutics  •  2007  |  View Paper
Similarly, pretreatment with low doses of the dopamine antagonist drug alpha-flupenthixol produced dose-dependent increases in cocaine but not heroin self-administration.
Psychopharmacology  •  2004  |  View Paper
The dopamine antagonist cis-flupentixol (0.48 mg/kg) blocked the substitution of nicotine for cocaine.
Psychopharmacology  •  2003  |  View Paper
Higher doses of flupenthixol (0.01-0.032 mg/kg) produced a surmountable blockade of both the discriminative stimulus and reinforcing effects of cocaine , shifting the dose-effect curves for both cocaine discrimination and cocaine self-administration up to 0.5 log unit to the right.
Similarly, doses of flupenthixol that decreased cocaine self-administration also often decreased rates of food-maintained responding.
The Journal of pharmacology and experimental therapeutics  •  1996  |  View Paper
Pretreatment with a dopamine antagonist, flupenthixol (0.018 mg/kg), antagonized the discriminative stimulus effects of cocaine but did not affect the cocaine-like effects of heroin.
The Journal of pharmacology and experimental therapeutics  •  1995  |  View Paper
In addition, both the dopamine D1 antagonist SCH 23390 [R-(+)-7-chloro-8-hydroxy-3-methyl-1-…,3,4,5-tetrahydro- 1H-3-benzazepine], the D2 antagonist eticlopride and the dopamine D1/D2 antagonist flupenthixol produced dose-dependent blockade … induced by either cocaine or methylphenidate.(ABSTRACT … AT 250 WORDS)
The Journal of pharmacology and experimental therapeutics  •  1995  |  View Paper
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