Possible Interaction: Cocaine and Flupenthixol

“The effects of methylphenidate and cocaine on responding for social play, but not their play-suppressant effects, were blocked by pretreatment with the dopamine receptor antagonist α-flupenthixol.”

“Infusion … α-flupenthixol into the ventral nucleus accumbens (NAcc) shell inhibited the acquisition of cocaine self-administration, reduced responding for the drug … FR-1 and PR schedules of reinforcement, and caused a downward shift of the dose–response curve of cocaine self-administration under an …-1 schedule of reinforcement.”

“ α-Flupenthixol increased cocaine but not sucrose intake under an FR-1 schedule of reinforcement.”

“ α-Flupenthixol blocked the development of both cocaine- and morphine-induced CPP but did not affect the development of sensitization to either drug.”

“The priming effects of cocaine were antagonized by clonidine and flupenthixol.”

“Similarly, pretreatment with low doses of the dopamine antagonist drug alpha-flupenthixol produced dose-dependent increases in cocaine but not heroin self-administration.”

“The dopamine antagonist cis-flupentixol (0.48 mg/kg) blocked the substitution of nicotine for cocaine.”

“Higher doses of flupenthixol (0.01-0.032 mg/kg) produced a surmountable blockade of both the discriminative stimulus and reinforcing effects of cocaine , shifting the dose-effect curves for both cocaine discrimination and cocaine self-administration up to 0.5 log unit to the right.”

“Similarly, doses of flupenthixol that decreased cocaine self-administration also often decreased rates of food-maintained responding.”

“Pretreatment with a dopamine antagonist, flupenthixol (0.018 mg/kg), antagonized the discriminative stimulus effects of cocaine but did not affect the cocaine-like effects of heroin.”

“In addition, both the dopamine D1 antagonist SCH 23390 [R-(+)-7-chloro-8-hydroxy-3-methyl-1-…,3,4,5-tetrahydro- 1H-3-benzazepine], the D2 antagonist eticlopride and the dopamine D1/D2 antagonist flupenthixol produced dose-dependent blockade … induced by either cocaine or methylphenidate.(ABSTRACT … AT 250 WORDS)”